LRCH3 and MYO6

Data Source:
BioGRID (two hybrid)

		LRCH3	MYO6
Description		leucine rich repeats and calponin homology domain containing 3	myosin VI
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	Septin Cytoskeleton Organization	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion
Pathways			Gap junction degradation Trafficking of AMPA receptors
Drugs
Diseases			Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)	Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		5 interacting genes: DGCR6L DNAAF11 MYO6 PIH1D1 YWHAG	20 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2
Entrez ID		84859	4646
HPRD ID		14308	02985
Ensembl ID		ENSG00000186001	ENSG00000196586
Uniprot IDs		B4DU23 Q96II8	Q9UM54
PDB IDs			2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56
Enriched GO Terms of Interacting Partners?
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