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NFKBID and POMC
Data Source:
BioGRID
(two hybrid)
NFKBID
POMC
Description
NFKB inhibitor delta
proopiomelanocortin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Extracellular Region
Extracellular Space
Cytoplasm
Secretory Granule
Secretory Granule Lumen
Molecular Function
Protein Binding
G Protein-coupled Receptor Binding
Signaling Receptor Binding
Hormone Activity
Protein Binding
Type 3 Melanocortin Receptor Binding
Type 4 Melanocortin Receptor Binding
Type 1 Melanocortin Receptor Binding
Biological Process
Inflammatory Response
Regulation Of Gene Expression
T Cell Receptor Signaling Pathway
Positive Regulation Of T-helper 17 Cell Differentiation
Generation Of Precursor Metabolites And Energy
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Cell-cell Signaling
Regulation Of Blood Pressure
Cytokine-mediated Signaling Pathway
Regulation Of Appetite
Negative Regulation Of Tumor Necrosis Factor Production
Cellular Pigmentation
Glucose Homeostasis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Glycogen Metabolic Process
Regulation Of Corticosterone Secretion
Pathways
Opioid Signalling
Androgen biosynthesis
Glucocorticoid biosynthesis
G-protein activation
Peptide hormone biosynthesis
Endogenous sterols
Peptide ligand-binding receptors
G alpha (s) signalling events
G alpha (i) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Interleukin-4 and Interleukin-13 signaling
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Loperamide
Etorphine
Dihydromorphine
Diseases
GWAS
Body mass index (
26426971
23669352
20935630
)
Body mass index (age <50) (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Crohn's disease (
28067908
)
Height (
28552196
23563607
18391951
)
Inflammatory bowel disease (
28067908
)
Obesity (
23563607
)
Pubertal anthropometrics (
23449627
)
Red vs. brown/black hair color (
30531825
)
Type 1 diabetes (
21980299
)
Interacting Genes
110 interacting genes:
ADAMTSL4
ANXA11
ARHGEF2
BEX2
C1orf109
C1orf94
C4orf45
CCHCR1
CRYBA2
CTRC
CYB5R2
DDX25
DMRT3
DTX3
EFHC2
ELOA
ESR2
FAAP20
FAM107A
FARS2
FOXI1
GADD45GIP1
GFAP
GIGYF1
GLYCTK
GPANK1
GRB10
HDAC4
HNRNPF
HNRNPH1
HOXA1
HOXB5
HOXC8
HOXC9
HOXD3
HSBP1L1
IHO1
IKZF3
INCA1
IRX6
KICS2
KRT19
KRT34
KRT40
KRT75
KRT76
KRTAP6-2
LCK
LGALS14
LHX3
LMO2
LMO3
LMO4
MEOX2
MRPL28
MRPL53
MYEF2
NCK2
NDUFB7
NICN1
NUP54
PATL1
PATZ1
PAX6
PKP1
PLEKHN1
POMC
POU4F2
PRDM6
PRMT7
PSMB8
PTCD1
QARS1
RAD51D
RBM14
RBM41
RBM4B
RFX2
RING1
RTP5
RUNX1
SAMD11
SAMD4A
SCNM1
SH2D1B
SH3RF1
SLU7
SMAD4
SMG9
SNAPC3
SORBS3
SS18
SSC4D
TCF19
TCF4
TCL1A
TEKT4
TEKT5
TFIP11
TRAF2
TRIM29
TRIM9
TRIML2
TSEN54
TSSK3
UTP23
VIM
ZBTB16
ZC2HC1B
ZIC1
28 interacting genes:
ABI2
APP
ATP6V0D2
BHLHA9
C1orf109
CCDC102B
ESRRG
FGF10
GLYCTK
HDDC2
HLA-DRB3
HSF2BP
KLHL42
MC1R
MC2R
MC3R
MC4R
MC5R
MEP1A
MKRN3
NFKBID
NRDC
NTAQ1
OAZ3
PAM
SUOX
TXN2
VTN
Entrez ID
84807
5443
HPRD ID
18140
01462
Ensembl ID
ENSG00000167604
ENSG00000115138
Uniprot IDs
Q8NI38
P01189
PDB IDs
4XNH
4XPD
4Y49
6TUB
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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