SMARCA5 and BAZ1A

Data Source:
HPRD (in vivo, in vitro)

		SMARCA5	BAZ1A
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	bromodomain adjacent to zinc finger domain 1A
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GO Annotations	Cellular Component	Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Cytosol NURF Complex RSF Complex Intracellular Membrane-bounded Organelle Nuclear Replication Fork	Nuclear Chromosome CHRAC ACF Complex
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity ATPase Activity Nucleosome Binding Histone Binding	Histone Acetyltransferase Activity Protein Binding Metal Ion Binding
	Biological Process	RDNA Heterochromatin Assembly Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription, Initiation Regulation Of Transcription By RNA Polymerase II Nucleosome Positioning CENP-A Containing Nucleosome Assembly ATP-dependent Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor	DNA-dependent DNA Replication Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Histone Acetylation
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere
Drugs		Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
Diseases
GWAS		Height ( 31562340) Malaria ( 31844061)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Non-small cell lung cancer ( 31326317) Red blood cell count ( 32888494) Response to bupropion in depression ( 27622933) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		18 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B H3-3A H3C1 H4-16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1	11 interacting genes: CHRAC1 MTNR1A POLE3 SATB1 SMAD2 SMAD9 SMARCA5 SRPK2 SUMO2 XRCC5 XRCC6
Entrez ID		8467	11177
HPRD ID		04538	12034
Ensembl ID		ENSG00000153147	ENSG00000198604
Uniprot IDs		O60264	Q9NRL2
PDB IDs		6NE3	5UIY
Enriched GO Terms of Interacting Partners?
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