IL1F10 and IL1R1

Data Source:
HPRD (in vitro)

		IL1F10	IL1R1
Description		interleukin 1 family member 10	interleukin 1 receptor type 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding	Protease Binding Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Inflammatory Response To Antigenic Stimulus Inflammatory Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus	Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-38 signaling Interleukin-36 pathway	Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS
Drugs			Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)
Diseases
GWAS		C-reactive protein ( 22939635) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory biomarkers ( 24182552) Interleukin-1-receptor antagonist levels ( 22205395) Low density lipoprotein cholesterol levels ( 32154731) Stroke ( 26089329) Total cholesterol levels ( 29083408)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Ankylosing spondylitis ( 23749187) Asthma ( 31959851 30929738 31619474 29785011 22561531) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576 28240269) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		2 interacting genes: IL1R1 IMPDH2	11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP
Entrez ID		84639	3554
HPRD ID		17144	00994
Ensembl ID		ENSG00000136697	ENSG00000115594
Uniprot IDs		Q8WWZ1	B8ZZW4 P14778
PDB IDs		5BOW	1G0Y 1IRA 1ITB 4DEP 4GAF
Enriched GO Terms of Interacting Partners?
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