KRTAP4-4 and GNE

Data Source:
BioGRID (two hybrid)

		KRTAP4-4	GNE
Description		keratin associated protein 4-4	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	Keratinization	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		Keratinization	Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM) Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS			Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		67 interacting genes: ADAMTSL4 ALX1 AQP1 BAG4 CATSPER1 CBX2 CRCT1 CREB5 CYSRT1 GLRX3 GNE HEY2 HOXA1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-6 KRTAP10-8 KRTAP12-1 KRTAP12-3 KRTAP13-2 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-2 KRTAP4-5 KRTAP5-11 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3B LCE3C LCE3E LCE4A LCE5A MEOX2 NBPF19 NOTCH2NLA NPDC1 NR4A3 NUFIP2 OTX1 POU4F2 SHFL SMCP TNS2 TRIM42 ZNF440 ZNF497 ZNF764	65 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16
Entrez ID		84616	10020
HPRD ID		13945	04825
Ensembl ID		ENSG00000171396	ENSG00000159921
Uniprot IDs		Q9BYR3	Q9Y223
PDB IDs			2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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