AKT1S1 and RPS6KA5

Data Source:
BioGRID (two hybrid)

		AKT1S1	RPS6KA5
Description		AKT1 substrate 1	ribosomal protein S6 kinase A5
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Negative Regulation Of TOR Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Response To Heat	Negative Regulation Of Cytokine Production Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway
Pathways		MTOR signalling mTORC1-mediated signalling AKT phosphorylates targets in the cytosol HSF1-dependent transactivation Constitutive Signaling by AKT1 E17K in Cancer	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS			Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: AKT1 AKT2 EIF6 FZR1 MTOR RPS6KA5 TCEA2 YWHAG YWHAQ	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AW H2BC21 H2BC3 H2BU1 H3-4 H3C14 H3C6 H4-16 H4C14 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		84335	9252
HPRD ID		12441	06789
Ensembl ID		ENSG00000204673	ENSG00000100784
Uniprot IDs		A0A024QZF6 Q96B36	O75582
PDB IDs		5WBL 5WBU 5WBY 6SB0	1VZO 3KN5 3KN6
Enriched GO Terms of Interacting Partners?
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