SLA2 and LAMC2

Data Source:
BioGRID (far western blotting)

		SLA2	LAMC2
Description		Src like adaptor 2	laminin subunit gamma 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Late Endosome Golgi Apparatus Plasma Membrane Phosphatidylinositol 3-kinase Complex Endosome Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Signaling Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity Protein N-terminus Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Mediated Immunity T Cell Activation Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway	Cell Adhesion Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Epidermis Development Animal Organ Morphogenesis Tissue Development Dendrite Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly
Pathways		Negative regulation of FLT3	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS			Acne (severe) ( 30542056) Blood protein levels ( 30072576 29875488) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Low density lipoprotein cholesterol levels ( 32154731) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)
Interacting Genes		14 interacting genes: CBL CD247 CSF1 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LAMC2 MET PRKAA2 UBASH3A ZAP70	7 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SLA2
Entrez ID		84174	3918
HPRD ID		05955	01031
Ensembl ID		ENSG00000101082	ENSG00000058085
Uniprot IDs		Q9H6Q3	Q13753
PDB IDs		4M4Z
Enriched GO Terms of Interacting Partners?
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