DTNBP1 and TPMT

Data Source:
BioGRID (biochemical)

		DTNBP1	TPMT
Description		dystrobrevin binding protein 1	thiopurine S-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Sarcoplasm Axon Growth Cone Midbody Synaptic Vesicle Membrane BLOC-1 Complex Melanosome Membrane Sarcolemma Neuron Projection Dendritic Spine Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm	Cytosol
	Molecular Function	Protein Binding	Protein Binding Thiopurine S-methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Negative Regulation Of Protein Kinase Activity Blood Coagulation Anterograde Axonal Transport Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Neuron Projection Development Actin Cytoskeleton Reorganization Negative Regulation Of Protein Binding Melanosome Organization Regulation Of JUN Kinase Activity Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis	Nucleobase-containing Compound Metabolic Process Drug Metabolic Process Methylation
Pathways		Golgi Associated Vesicle Biogenesis	Methylation Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Drugs			Olsalazine
Diseases		Hermansky-Pudlak syndrome (HPS)	Thiopurine S-methyltransferase deficiency (TPMT deficiency)
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Multiple myeloma ( 27363682) Squamous cell carcinoma ( 31174203)	DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte thioguanine concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Thiopurine methyltransferase activity in acute lymphoblastic leukemia patients treated with mercaptopurines ( 27564568) Thiopurine S-methyltransferase activity ( 27770449) Thiopurine-induced myelosuppression in inflammatory bowel disease ( 30806694)
Interacting Genes		50 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S5 BLOC1S6 BRF1 CCDC146 CCDC153 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DST DTNA DTNB ELOVL7 HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 KRT75 MACF1 NBEA NDN NECAB2 NUF2 OIP5 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TRAF3IP1 TRIM2 TRIM27 TRIM9 VRK2 WASHC3 ZNF490	1 interacting genes: APP
Entrez ID		84062	7172
HPRD ID		06190	01760
Ensembl ID		ENSG00000047579	ENSG00000137364
Uniprot IDs		A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8	A0A024QZW0 P51580
PDB IDs			2BZG 2H11
Enriched GO Terms of Interacting Partners?
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