OBSCN and ANK2

Data Source:
HPRD (in vitro)

		OBSCN	ANK2
Description		obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	ankyrin 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Nuclear Body Myofibril Z Disc M Band Sarcolemma	Mitochondrion Lysosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Postsynaptic Membrane Recycling Endosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Cell Adhesion Molecule Binding Phosphatidylinositol-4-phosphate Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein-macromolecule Adaptor Activity Ion Channel Binding ATPase Binding Phosphorylation-dependent Protein Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Protein Localization To M-band Positive Regulation Of Apoptotic Process Sarcomere Organization Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Cell-cell Adhesion	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endocytosis Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Protein Transport Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033 32439900)	Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Chronotype ( 30696823) Diastolic blood pressure ( 31469255) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Coprococcus) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Ischemic stroke ( 29531354) Parkinson's disease ( 28892059) Periventricular white matter hyperintensities ( 32517579) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Stroke ( 29531354)
Interacting Genes		8 interacting genes: ANK1 ANK2 BRCA1 CALM1 DNAJB5 MTDH MYH2 TTN	20 interacting genes: ANKRD28 DNAJB1 DNAJB5 ECPAS EPB42 GABARAP GABARAPL1 GABARAPL2 L1CAM MAP1LC3A MAP1LC3B MAP1LC3C NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53
Entrez ID		84033	287
HPRD ID		10551	00110
Ensembl ID		ENSG00000154358	ENSG00000145362
Uniprot IDs		A6NGQ3 Q5VST9	Q01484
PDB IDs		1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9	4D8O 4RLV 4RLY 5Y4D 5Y4E 5Y4F 5YIR 5YIS 6KZJ 6M3Q
Enriched GO Terms of Interacting Partners?
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