KRTAP3-1 and GPS2

Data Source:
BioGRID (two hybrid)

		KRTAP3-1	GPS2
Description		keratin associated protein 3-1	G protein pathway suppressor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Nucleus Nucleoplasm Mitochondrion Cytosol Transcription Repressor Complex
	Molecular Function	Structural Molecule Activity Protein Binding	Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process	Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Viral Process Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		Keratinization	PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS
Interacting Genes		82 interacting genes: ADAM12 AGXT ANAPC11 BMP7 C20orf85 CDKN1A CELA2B CERK CFP CNNM3 CREB5 CTRC CYSRT1 DMRT3 DOCK2 FAM168A FAM222B FOXH1 FRS3 GATA2 GNE GPS2 GSTP1 HCK HEY2 HOXB9 HR HSF4 IL16 ITGB4 KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP9-3 KRTAP9-8 LCE1B LCE2B LCE3A LCE3D LCE4A LCE5A LMO4 LRRC41 MAPKBP1 MRPL40 MYPOP NOTCH2NLA NTAQ1 OTX1 PATZ1 PCSK5 PHLDA1 PKIB PLSCR4 POLR1C PPP1R32 PTPMT1 PVR RBPMS RECK REEP6 RNF44 SAMD7 SMARCC1 SPAG8 TEKT3 TEX37 TLX3 TNS2 VASN VENTX VGLL3 WDR25 YPEL3 ZFHX2 ZNF414 ZNF446	53 interacting genes: AKAP8L ATF4 ATF5 BAG4 BRME1 C19orf54 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C
Entrez ID		83896	2874
HPRD ID		13937	11878
Ensembl ID		ENSG00000212901	ENSG00000132522
Uniprot IDs		Q9BYR8	Q13227
PDB IDs			2L5G
Enriched GO Terms of Interacting Partners?
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