H2AB3 and H2BC13

Data Source:
BioGRID (two hybrid)

		H2AB3	H2BC13
Description		H2A.B variant histone 3	H2B clustered histone 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Transcriptionally Active Chromatin	Nucleosome Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly Chromatin Silencing MRNA Processing	Nucleosome Assembly Protein Ubiquitination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: H2BC13 H2BC15 MESD	5 interacting genes: AP2M1 CDC42 H2AB2 H2AB3 VHL
Entrez ID		83740	8340
HPRD ID		06581	11898
Ensembl ID		ENSG00000277745	ENSG00000185130
Uniprot IDs		P0C5Z0	Q99880
PDB IDs		6A7U 6M4G 6M4H
Enriched GO Terms of Interacting Partners?
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