SH3BGRL3 and TNFRSF8

		SH3BGRL3	TNFRSF8
Description		SH3 domain binding glutamate rich protein like 3	TNF receptor superfamily member 8
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GO Annotations	Cellular Component	Cytoplasm Nuclear Body Extracellular Exosome	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein Disulfide Oxidoreductase Activity	Transmembrane Signaling Receptor Activity
	Biological Process		Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways			TNFs bind their physiological receptors
Drugs			XmAb 2513 Brentuximab vedotin
Diseases
GWAS			Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		5 interacting genes: APP CDC42 DDIT4L EGFR ERBB2	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		83442	943
HPRD ID		15332	01074
Ensembl ID		ENSG00000142669	ENSG00000120949
Uniprot IDs		Q9H299	A5D8T4 P28908
PDB IDs		1SJ6	1D01
Enriched GO Terms of Interacting Partners?
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