TNFRSF8

Description		TNF receptor superfamily member 8
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		TNFs bind their physiological receptors
Drugs		XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Novel Interacting Genes		7 novel interacting genes: CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 WRAP73
Interacting Genes		7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		943
HPRD ID		01074
Ensembl ID		ENSG00000120949
Uniprot IDs		A5D8T4 P28908
PDB IDs		1D01
Enriched GO Terms of Interacting Partners?
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