H2BC8 and UBR2

Data Source:
BioGRID (enzymatic study)

		H2BC8	UBR2
Description		H2B clustered histone 8	ubiquitin protein ligase E3 component n-recognin 2
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GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Protein Ubiquitination Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Protein Polyubiquitination Chromatin Silencing Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Negative Regulation Of Transposition Protein Ubiquitination Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper
Diseases
GWAS			Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein level ( 29403010)
Interacting Genes		7 interacting genes: AP2M1 ESR1 PTMA RAD51B TGM2 UBR2 YWHAQ	9 interacting genes: H2AC20 H2BC8 NTAN1 NTAQ1 PKN1 SUOX UBE2B UBE2D2 UBE2H
Entrez ID		8339	23304
HPRD ID		11897	09853
Ensembl ID		ENSG00000273802	ENSG00000024048
Uniprot IDs		B2R4S9 P62807	B3KXG6 Q8IWV8
PDB IDs		5GT0 5KGF 6ACO 6C0W 6FML 6R0C 6RNY 6SE0 6SE6 6SEE 6SEF 6SEG 6UPK 6UPL 6X59 6X5A 6XJD 7A08 7JO9 7JOA	3NY2 3NY3 5TDA 5TDB 5TDD 5UM3
Enriched GO Terms of Interacting Partners?
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