FZD9 and WNT7A

Data Source:
HPRD (in vivo)

		FZD9	WNT7A
Description		frizzled class receptor 9	Wnt family member 7A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Filopodium Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Protein Heterodimerization Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Ossification Release Of Cytochrome C From Mitochondria G Protein-coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory B Cell Differentiation Positive Regulation Of Bone Mineralization Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Canonical Wnt Signaling Pathway Postsynapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Bone Regeneration Positive Regulation Of Neural Precursor Cell Proliferation	Embryonic Axis Specification Cartilage Condensation Angiogenesis Chondrocyte Differentiation Neurotransmitter Secretion Axonogenesis Sex Differentiation Dorsal/ventral Pattern Formation Positive Regulation Of Endothelial Cell Migration Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Cerebellar Granule Cell Differentiation Cell Proliferation In Forebrain Central Nervous System Vasculogenesis Establishment Of Cell Polarity Neuron Differentiation Regulation Of Axon Diameter Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Synaptic Vesicle Recycling Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Response To Estrogen Cell Fate Commitment Asymmetric Protein Localization Involved In Cell Fate Determination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Somatic Stem Cell Division Stem Cell Development Negative Regulation Of Neurogenesis Positive Regulation Of Synapse Assembly Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Oviduct Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Dendritic Spine Morphogenesis Uterus Morphogenesis Secondary Palate Development Lens Fiber Cell Development Cellular Response To Transforming Growth Factor Beta Stimulus Presynapse Assembly Postsynapse Assembly Regulation Of Postsynapse Organization Excitatory Synapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Presynapse Assembly Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Class B/2 (Secretin family receptors)	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases			Fuhrmann syndrome; Fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly Al-Awadi/Raas-Rothschild syndrome; Ulna and fibula, absence of, with sever limb deficiency
GWAS		HDL cholesterol levels ( 32203549) Lamb consumption ( 32066663) Malaria ( 31844061) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Protein C levels ( 28082259)	Body mass index ( 26426971) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31152163 29124443) Glomerular filtration rate (creatinine) ( 26831199) Hematocrit ( 32888494) Pulse pressure ( 27841878 30578418) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Serum uric acid levels ( 29124443)
Interacting Genes		6 interacting genes: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A	3 interacting genes: FZD5 FZD9 STRN4
Entrez ID		8326	7476
HPRD ID		03460	03341
Ensembl ID		ENSG00000188763	ENSG00000154764
Uniprot IDs		O00144	O00755
PDB IDs			4UZQ
Enriched GO Terms of Interacting Partners?
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