FZD8 and GOPC

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FZD8	GOPC
Description		frizzled class receptor 8	golgi associated PDZ and coiled-coil motif containing
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity	Protein Binding Identical Protein Binding Ion Channel Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuron Differentiation Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface
Pathways		Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants	RHO GTPases regulate CFTR trafficking
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)	Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Night sleep phenotypes ( 27126917)
Interacting Genes		5 interacting genes: GOPC LRP5 LRP6 RYK WNT1	70 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 ATG9A BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1
Entrez ID		8325	57120
HPRD ID		05852	06024
Ensembl ID		ENSG00000177283	ENSG00000047932
Uniprot IDs		Q9H461	Q9HD26
PDB IDs		5UN5 5UN6 6NDZ	2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6XNJ
Enriched GO Terms of Interacting Partners?
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