COLQ and MUSK

Data Source:
HPRD (in vivo)

		COLQ	MUSK
Description		collagen like tail subunit of asymmetric acetylcholinesterase	muscle associated receptor tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Collagen Trimer Basement Membrane Extracellular Space Plasma Membrane Cell Junction Extracellular Matrix Synaptic Cleft Collagen-containing Extracellular Matrix	Integral Component Of Plasma Membrane Neuromuscular Junction Receptor Complex Postsynaptic Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Acetylcholine Catabolic Process In Synaptic Cleft Extracellular Matrix Organization	Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Protein Autophosphorylation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation
Pathways			ECM proteoglycans
Drugs			Fostamatinib
Diseases		Congenital myasthenic syndrome	Congenital myasthenic syndrome
GWAS		Diverticular disease ( 30177863 28585551) Diverticulitis ( 28585551)	Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		4 interacting genes: ACHE BCHE MUSK SGTB	7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1
Entrez ID		8292	4593
HPRD ID		04328	03190
Ensembl ID		ENSG00000206561	ENSG00000030304
Uniprot IDs		Q9Y215	A0A087WSY1 O15146
PDB IDs		1VZJ
Enriched GO Terms of Interacting Partners?
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