NAA10 and TSEN54

Data Source:
BioGRID (two hybrid)

		NAA10	TSEN54
Description		N-alpha-acetyltransferase 10, NatA catalytic subunit	tRNA splicing endonuclease subunit 54
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Membrane NatA Complex	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus
	Molecular Function	Peptide Alpha-N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Acetyltransferase Activity Ribosome Binding Peptide-serine-N-acetyltransferase Activity Peptide-glutamate-N-acetyltransferase Activity	Protein Binding
	Biological Process	DNA Packaging Protein Acetylation N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation N-terminal Peptidyl-serine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing
Pathways			tRNA processing in the nucleus
Drugs
Diseases			Pontocerebellar hypoplasia
GWAS		Systemic lupus erythematosus ( 26502338)	Deep white matter hyperintensities ( 32517579) FEV1 ( 30804560) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Platelet count ( 32888494) Plateletcrit ( 32888494) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370)
Interacting Genes		55 interacting genes: ACOT12 BAALC BCOR CALCOCO2 CASP8AP2 CCDC106 CCDC174 CDC25A CDCA5 CEP44 CREB3 CREBRF DDIT4L DHX57 EHMT2 FIP1L1 GPATCH2L HIF1A HIF1AN HSPA4 KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 MCRS1 MDM4 MEOX2 MKRN1 MRPS11 NAA15 NAA16 NAA50 NAT1 NAT2 NOXA1 PDE4DIP PGK1 PLSCR3 PPP2R3B PSME2 RAB3IP RBCK1 RCN3 RIMBP2 RPL26 SEMA3B SNX33 SSX2IP TAF7L TSEN54 UBC ZBTB14 ZNF202 ZNF655	21 interacting genes: BRCA1 CCDC57 CLP1 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12
Entrez ID		8260	283989
HPRD ID		02056	12291
Ensembl ID		ENSG00000102030	ENSG00000182173
Uniprot IDs		B7Z9N2 P41227	Q7Z6J9
PDB IDs		6C95 6C9M 6PPL 6PW9
Enriched GO Terms of Interacting Partners?
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