CLTCL1 and SNX5

Data Source:
HPRD (two hybrid, in vivo)

		CLTCL1	SNX5
Description		clathrin heavy chain like 1	sorting nexin 5
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Late Endosome Trans-Golgi Network Spindle Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Coated Vesicle Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Recycling Endosome Extracellular Exosome Clathrin Complex Sorting Endosome	Ruffle Phagocytic Cup Endosome Cytosol Brush Border Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Light Chain Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Mitotic Cell Cycle Intracellular Protein Transport Receptor-mediated Endocytosis Anatomical Structure Morphogenesis Retrograde Transport, Endosome To Golgi Positive Regulation Of Glucose Import Membrane Organization	Intracellular Protein Transport Pinocytosis Epidermal Growth Factor Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Renal Sodium Excretion Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Metabolite levels ( 22916037)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		3 interacting genes: EGFR PICALM SNX5	19 interacting genes: APPBP2 AQP2 BANP CDC37 CLTC CLTCL1 DDX58 DNAJB11 FANCA HGS HMOX2 ITSN1 LAMTOR5 MESD MIB1 PFDN1 PRKRA PSMB8 SNX2
Entrez ID		8218	27131
HPRD ID		03172	10439
Ensembl ID		ENSG00000070371	ENSG00000089006
Uniprot IDs		P53675	Q6P5V6 Q9Y5X3
PDB IDs			1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z
Enriched GO Terms of Interacting Partners?
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