TSPAN14 and ATP13A2

Data Source:
BioGRID (two hybrid)

		TSPAN14	ATP13A2
Description		tetraspanin 14	ATPase cation transporting 13A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Tertiary Granule Membrane Tetraspanin-enriched Microdomain	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Integral Component Of Membrane Transport Vesicle Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen Integral Component Of Lysosomal Membrane
	Molecular Function	Protein Binding Enzyme Binding	Protein Binding ATP Binding Zinc Ion Binding ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity Manganese Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Cupric Ion Binding
	Biological Process	Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Notch Signaling Pathway Protein Maturation Protein Localization To Plasma Membrane	Cellular Calcium Ion Homeostasis Cellular Iron Ion Homeostasis Cellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Cellular Cation Homeostasis Regulation Of Intracellular Protein Transport Ion Transmembrane Transport Cellular Response To Oxidative Stress Protein Autophosphorylation Positive Regulation Of Protein Secretion Regulation Of Endopeptidase Activity Zinc Ion Homeostasis Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process Peptidyl-aspartic Acid Autophosphorylation Regulation Of Ubiquitin-specific Protease Activity
Pathways		Neutrophil degranulation Amyloid fiber formation	Ion transport by P-type ATPases
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Birth weight ( 31043758) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 29212778 33020668) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Periventricular white matter hyperintensities ( 32517579) Post bronchodilator FEV1 ( 26634245) Pulse pressure ( 30224653) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) White blood cell count ( 32888494)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		1 interacting genes: ATP13A2	36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS
Entrez ID		81619	23400
HPRD ID		18196	13677
Ensembl ID		ENSG00000108219	ENSG00000159363
Uniprot IDs		Q8NG11	Q8N4D4 Q8NBS1 Q9NQ11
PDB IDs
Enriched GO Terms of Interacting Partners?
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