SSPN and SGCG

Data Source:
HPRD (in vivo, in vitro)

		SSPN	SGCG
Description		sarcospan	sarcoglycan gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Dystrophin-associated Glycoprotein Complex Transport Vesicle Sarcolemma Postsynaptic Membrane	Cytoplasm Cytoskeleton Plasma Membrane Sarcoglycan Complex Integral Component Of Membrane Sarcolemma
	Molecular Function		Protein Binding
	Biological Process	Muscle Contraction Cell Adhesion	Muscle Organ Development Cardiac Muscle Tissue Development Heart Contraction
Pathways
Drugs
Diseases			Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F Limb-girdle muscular dystrophy (LGMD)
GWAS		Atrial fibrillation ( 30061737 29892015) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Monocyte count ( 32888494) PR interval ( 32439900) Triglyceride levels ( 32203549) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494)	Alanine aminotransferase levels ( 31219225) Asthma ( 27611488) Atrial fibrillation ( 30061737) Bipolar disorder ( 21738484) Central corneal thickness ( 29760442) Corneal structure ( 23291589) Number of alcoholic drinks required to feel an effect (first five times drinking) ( 31270906) Type 2 diabetes ( 23300278)
Interacting Genes		2 interacting genes: SGCG SMO	20 interacting genes: APP CCT6A CLDN5 DNAJB6 DYSF ENO1 ENO3 FLNC HSPA1B MYBPC1 MYBPC2 MYLPF PSAP PYGM SGCB SGCD SPACA1 SSPN SUCLG2 TTN
Entrez ID		8082	6445
HPRD ID		03359	07039
Ensembl ID		ENSG00000123096	ENSG00000102683
Uniprot IDs		Q14714	Q13326
PDB IDs
Enriched GO Terms of Interacting Partners?
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