TSEN2 and NUP210

Data Source:
BioGRID (biochemical)

		TSEN2	NUP210
Description		tRNA splicing endonuclease subunit 2	nucleoporin 210
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus Centrosome Cytosol	Nuclear Envelope Nuclear Pore Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane Host Cell
	Molecular Function	TRNA-intron Endonuclease Activity Nucleic Acid Binding Protein Binding Lyase Activity
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Protein-containing Complex Assembly Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		tRNA processing in the nucleus	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases		Pontocerebellar hypoplasia
GWAS		Systemic lupus erythematosus ( 28714469) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Coronary artery disease in type 1 diabetes ( 29695241)
Interacting Genes		7 interacting genes: CADPS CTAG2 GABPB2 RANBP10 TAX1BP1 TEPSIN TSEN54	4 interacting genes: CDK1 EXOSC5 MTDH TRIP6
Entrez ID		80746	23225
HPRD ID		10576	06368
Ensembl ID		ENSG00000154743	ENSG00000132182
Uniprot IDs		A0A024R2G3 Q8NCE0	Q8TEM1
PDB IDs
Enriched GO Terms of Interacting Partners?
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