PDHX and PDHB

Data Source:
HPRD (in vivo)

		PDHX	PDHB
Description		pyruvate dehydrogenase complex component X	pyruvate dehydrogenase E1 subunit beta
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Binding Transferase Activity, Transferring Acyl Groups Pyruvate Dehydrogenase (NAD+) Activity	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Pyruvate Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs			Pyruvic acid NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Bone mineral density (hip) ( 30172743) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Uterine fibroids ( 30194396 31649266)	Apolipoprotein B levels ( 32203549) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) IgG levels ( 28628107) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) vWF levels ( 30586737)
Interacting Genes		10 interacting genes: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 PDHB PDK2	17 interacting genes: ADORA2A AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1
Entrez ID		8050	5162
HPRD ID		02002	01530
Ensembl ID		ENSG00000110435	ENSG00000168291
Uniprot IDs		O00330	A0A384MDR8 P11177
PDB IDs		1ZY8 2DNC 2F5Z 2F60 6H60	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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