WDR61 and MSRB3

Data Source:
BioGRID (two hybrid)

		WDR61	MSRB3
Description		WD repeat domain 61	methionine sulfoxide reductase B3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Transcriptionally Active Chromatin Ski Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Protein Ubiquitination Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation	Response To Oxidative Stress Protein Repair
Pathways		Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Protein repair
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Reticulocyte count ( 32888494)	Antisaccade task score ( 31596458) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ	32 interacting genes: ASB13 BANP CTBP2 EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 WDR61 ZMYND12
Entrez ID		80349	253827
HPRD ID		15236	14785
Ensembl ID		ENSG00000140395	ENSG00000174099
Uniprot IDs		H0YL19 Q9GZS3	Q8IXL7
PDB IDs		3OW8 6GMH 6TED	6QA0
Enriched GO Terms of Interacting Partners?
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