PNPLA3 and AKT2

Data Source:
BioGRID (two hybrid)

		PNPLA3	AKT2
Description		patatin like phospholipase domain containing 3	AKT serine/threonine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Early Endosome Cytosol Plasma Membrane Cell Cortex Ruffle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Phospholipase A2 Activity Triglyceride Lipase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Response To Sucrose Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Insulin Stimulus Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling White Fat Cell Differentiation Lipid Homeostasis Cellular Response To 3,3',5-triiodo-L-thyronine	Positive Regulation Of Protein Phosphorylation Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Cellular Protein Modification Process Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Carbohydrate Transport Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Vesicle Fusion Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Mammary Gland Epithelial Cell Differentiation Intracellular Protein Transmembrane Transport Regulation Of Cell Cycle Arrest Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Activation Of GTPase Activity Retinal Rod Cell Apoptotic Process Positive Regulation Of Cell Motility
Pathways		Acyl chain remodeling of DAG and TAG	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs			N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases			Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Ovarian cancer
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alanine aminotransferase levels ( 30718733 31219225) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 31219225 29403010) Cirrhosis ( 31815349) Cirrhosis (alcohol related) ( 26482880) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatic lipid content in extreme obesity ( 25246029) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 21909109) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Nonalcoholic fatty liver disease ( 32298765 21423719 24531328 22719876 29271184 29385134 31311600) Nonalcoholic steatohepatitis ( 32298765) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Serum uric acid levels ( 30993211) Total cholesterol levels ( 31217584 30275531) Total triglycerides levels ( 26690388) Triacylglycerol 56:6 levels ( 31560688) Type 2 diabetes ( 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528)	Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		3 interacting genes: AKT2 LINC00839 SNX27	44 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SNX27 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP
Entrez ID		80339	208
HPRD ID		12430	01262
Ensembl ID		ENSG00000100344	ENSG00000105221
Uniprot IDs		Q9NST1	B4DG79 P31751
PDB IDs			1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D
Enriched GO Terms of Interacting Partners?
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