EPC1 and NPHP3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		EPC1	NPHP3
Description		enhancer of polycomb homolog 1	nephrocystin 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Membrane Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Intracellular Membrane-bounded Organelle	Extracellular Region Cytosol Cilium
	Molecular Function	Histone Acetyltransferase Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Kidney Development Heart Looping Atrial Septum Development Determination Of Left/right Symmetry Wnt Signaling Pathway Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways		HATs acetylate histones Transcriptional Regulation by E2F6	Trafficking of myristoylated proteins to the cilium
Drugs
Diseases			Senior-Loken syndrome Renal-hepatic-pancreatic dysplasia Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Diastolic blood pressure ( 30224653) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252) Sexual dysfunction (female) ( 22509378)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 27182965 21102462) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: CHRM5 E2F6 HOPX KAT5 KRT15 MBTD1 RINT1 SYCE1L TRIM27	3 interacting genes: ATXN1 DYSF NPHP1
Entrez ID		80314	27031
HPRD ID		09941	06417
Ensembl ID		ENSG00000120616	ENSG00000113971
Uniprot IDs		Q9H2F5	Q7Z494
PDB IDs		6NFX	5L7K
Enriched GO Terms of Interacting Partners?
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