TET1 and DDX21

Data Source:
BioGRID (two hybrid)

		TET1	DDX21
Description		tet methylcytosine dioxygenase 1	DExD-box helicase 21
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GO Annotations	Cellular Component	Nucleus	Nucleoplasm Chromosome Nucleolus Mitochondrion Cytosol Membrane
	Molecular Function	DNA Binding Iron Ion Binding Zinc Ion Binding Methyl-CpG Binding Methylcytosine Dioxygenase Activity	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Inner Cell Mass Cell Differentiation 5-methylcytosine Catabolic Process Chromatin Organization Protein O-linked Glycosylation Positive Regulation Of Cell Population Proliferation Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Negative Regulation Of DNA Methylation-dependent Heterochromatin Assembly	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus R-loop Disassembly
Pathways		TET1,2,3 and TDG demethylate DNA	B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Childhood body mass index ( 33045005) Chronotype ( 30696823) Height ( 31562340) Pulse pressure ( 30224653) Triglycerides ( 30275531)	Depression (quantitative trait) ( 20800221)
Interacting Genes		1 interacting genes: MBD3	87 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN KPNA3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN SRPK2 SUMO2 TERF1 TERF2 UBE2I
Entrez ID		80312	9188
HPRD ID		09694	05895
Ensembl ID		ENSG00000138336	ENSG00000165732
Uniprot IDs		Q8NFU7	Q9NR30
PDB IDs		6ASD	2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?
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