CUBN and LRP2

Data Source:
HPRD (in vivo, in vitro)

		CUBN	LRP2
Description		cubilin	LDL receptor related protein 2
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GO Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Brush Border Membrane Lysosomal Lumen Receptor Complex Extracellular Exosome	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Brush Border Membrane Endosome Lumen Receptor Complex Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Cobalamin Binding Signaling Receptor Activity Cargo Receptor Activity Protein Homodimerization Activity	Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Hormone Binding Chaperone Binding Protein Transporter Activity
	Biological Process	Tissue Homeostasis Receptor-mediated Endocytosis Cholesterol Metabolic Process Cobalamin Metabolic Process Response To Bacterium Cobalamin Transport High-density Lipoprotein Particle Clearance Vitamin D Metabolic Process Lipoprotein Transport	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Protein Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Positive Regulation Of Protein Kinase B Signaling Vagina Development Coronary Artery Morphogenesis Membrane Organization Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Vitamin D (calciferol) metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CUBN causes hereditary megaloblastic anemia 1 HDL clearance	Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport
Drugs		Hydroxocobalamin	Urokinase Insulin pork Gentamicin
Diseases			Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Binge eating behaviour in bipolar disorder ( 29391396) Cholesterol, total ( 24097068) Colorectal cancer ( 25990418) Folate pathway vitamin levels ( 19303062 19744961) High density lipoprotein cholesterol levels ( 30498476) Homocysteine levels ( 23824729) Metabolite levels ( 23823483) Microalbuminuria ( 26631737 31511532) Molybdenum levels ( 26025379) Platelet distribution width ( 27863252) Plateletcrit ( 32888494) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Quantitative traits ( 19197348) Superior temporal gyrus volume ( 31530798) Total cholesterol levels ( 28334899) Total grey matter volume ( 31530798) Urate levels ( 31578528) Urinary albumin excretion ( 21355061 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 26631737 31630189 30910378 27650483 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Vitamin B levels in ischemic stroke ( 25147783) Whole-brain volume ( 21116278)	Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29124443 29403010) Urate levels ( 31578528 20139978)
Interacting Genes		9 interacting genes: ALB BRCA1 CBL CBLIF GC LGALS3 LRP2 SCGB1A1 TF	51 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		8029	4036
HPRD ID		04296	02509
Ensembl ID		ENSG00000107611	ENSG00000081479
Uniprot IDs		O60494	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		3KQ4 6GJE	2M0P
Enriched GO Terms of Interacting Partners?
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