FAM214B and ABI2

Data Source:
BioGRID (two hybrid)

		FAM214B	ABI2
Description		family with sequence similarity 214 member B	abl interactor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol Cytoskeleton Adherens Junction Lamellipodium SCAR Complex Filopodium Tip Dendritic Spine
	Molecular Function	Protein Binding	Protein Binding Cytoskeletal Anchor Activity SH3 Domain Binding Kinase Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Proline-rich Region Binding
	Biological Process		Cytoskeleton Organization Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Viral Process Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Butyrylcholinesterase levels ( 21862451) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		63 interacting genes: ABI2 AKAP8L APP BAG4 BHLHB9 C11orf65 C7orf57 CALCOCO2 CCDC125 CCDC33 CCDC85B CEP70 CYSRT1 DIP2A DNAJA3 EFHC2 EYA2 FHL2 FHL5 GOLGA2 HSF2BP HSPB8 IKZF1 KIF20A KPNA3 KPNA5 KRT34 KRTAP19-5 KRTAP19-6 KRTAP6-2 KRTAP6-3 LMO2 LZTS2 MDFI MID2 MKRN3 MYO1F MYO5B MYOZ3 NCOA5 PDLIM7 PFDN5 PICK1 PRDM6 PTPN21 RBM11 SFMBT1 SLAIN1 SORBS3 TBC1D23 TEPSIN TLE5 TRAF2 TRAF4 TRIM27 VPS9D1 WWOX WWP2 ZMYND12 ZNF219 ZNF572 ZNF655 ZRANB1	197 interacting genes: ABI1 ABI3 ABL1 ABL2 ABLIM3 ADAM19 AKAP8L AKAP9 ANKRD55 ANKS1A ARHGAP32 ARMC7 ATP23 BAG4 BIN3 BLOC1S5 BLOC1S6 BORCS6 C19orf54 C1orf109 C1orf216 C20orf202 C4orf17 CCDC102B CCDC115 CCDC57 CCDC74B CCHCR1 CDK6 CENPH CENPQ CEP44 CEP57 CLPP COG3 CRX CUEDC1 DCTN2 DISC1 DLGAP2 DLGAP4 DNAI7 DTNB EFS EGLN3 EGR4 EIF3H ENAH ENKD1 EPS8L1 FAM161B FAM166B FAM214B FAM90A1 FAM9C FBXL19 FHL5 FKBP1A FOXD4L1 GAS2L2 GCC1 GFAP GGN GPANK1 HGS HHEX HNRNPK HOMER3 HSF2BP IFT20 IHO1 INCA1 INO80B INSYN1 KHDRBS1 KIAA1217 KIFC3 KNSTRN KRT13 KRT14 KRT15 KRT19 KRT20 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT75 LENG1 LGALS9B LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LNX1 LURAP1 LZTS2 MAGEA1 MCM7 MED10 MED11 MED29 MEOX2 MRFAP1 MRFAP1L1 MRPL28 MRPL44 MYO15B MYOG MYOZ3 NCK1 NCK2 NCKIPSD NFASC NHSL2 NME4 NUP62 OIP5 OOEP PAK2 PCM1 PDLIM7 PFDN5 PHETA1 PHF1 PIN1 PLEKHN1 POMC PPIF PPP3CA PRAM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA1 PWWP2B RABEP1 RABGEF1 RASD1 RNPS1 RPP25 RSPH14 RUSC1 SCGN SDCBP SH3BP1 SH3KBP1 SLA SMARCB1 SMARCD1 SNAP23 SNAP91 SNAPIN SNX18 SNX7 SORBS3 STAM2 STX19 STX4 TFIP11 TLE5 TPM2 TRAF3IP1 TRIM32 TRIM72 TRIML2 TRIP6 UBQLN2 USHBP1 USP2 VARS2 VASP VCL VPS28 VPS37C WASF2 WASF3 WASHC1 WASHC3 WASL WIPF1 WWOX ZFP90 ZMYND12 ZNF474 ZNF688
Entrez ID		80256	10152
HPRD ID		13869	07338
Ensembl ID		ENSG00000005238	ENSG00000138443
Uniprot IDs		Q7L5A3	A0A0C4DG21 A0A7D9NKC8 B7Z836 F8WAL6 Q9NYB9
PDB IDs			2ED0 3P8C 4N78
Enriched GO Terms of Interacting Partners?
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