NUBPL and KDM8

Data Source:
BioGRID (two hybrid)

		NUBPL	KDM8
Description		nucleotide binding protein like	lysine demethylase 8
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Plasma Membrane	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Chromatin Binding Endopeptidase Activity Aminopeptidase Activity Protein Binding 2-oxoglutarate-dependent Dioxygenase Activity Methylated Histone Binding Metal Ion Binding Histone Demethylase Activity (H3-K36 Specific) L-arginine 3-hydroxylase Activity
	Biological Process	Iron-sulfur Cluster Assembly Mitochondrial Respiratory Chain Complex I Assembly Mitochondrion Morphogenesis	G2/M Transition Of Mitotic Cell Cycle Proteolysis Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Histone H3-K36 Demethylation
Pathways		Complex I biogenesis
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Bitter alcoholic beverage consumption ( 31046077) Brain lesion load ( 19010793) Response to iloperidone treatment (QT prolongation) ( 18521091)	Asthma ( 31959851 31619474) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917)
Interacting Genes		3 interacting genes: KDM8 MTUS2 NUBP2	6 interacting genes: DDIT4L IFT20 ISY1 MEOX2 NUBPL PCYT2
Entrez ID		80224	79831
HPRD ID		16600	07836
Ensembl ID		ENSG00000151413	ENSG00000155666
Uniprot IDs		B3KSK2 B4DWB0 Q8TB37 X5D2R5	A0A0S2Z5P8 A0A0S2Z5T1 Q8N371
PDB IDs			3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N
Enriched GO Terms of Interacting Partners?
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