TM2D3 and LRRK1

Data Source:
BioGRID (affinity chromatography technology)

		TM2D3	LRRK1
Description		TM2 domain containing 3	leucine rich repeat kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spanning Component Of Plasma Membrane	Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function		Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Positive Regulation Of Notch Signaling Pathway Lateral Inhibition	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Triglyceride levels ( 32154731)	Central corneal thickness ( 32528159 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)
Interacting Genes		2 interacting genes: ERRFI1 PAXIP1	51 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP VGLL4
Entrez ID		80213	79705
HPRD ID		16554	14319
Ensembl ID		ENSG00000184277	ENSG00000154237
Uniprot IDs		B4DLL2 E7EPS7 H0YNS4 Q9BRN9	Q38SD2
PDB IDs
Enriched GO Terms of Interacting Partners?
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