FBXO11 and BCL6

Data Source:
BioGRID (imaging technique, enzymatic study)

		FBXO11	BCL6
Description		F-box protein 11	BCL6 transcription repressor
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm Replication Fork Nucleolus Golgi Apparatus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-arginine N-methyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Sound Protein Ubiquitination Peptidyl-arginine N-methylation Regulation Of Apoptotic Process Post-translational Protein Modification	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Cytokine Production Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Immune System Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Protein Localization Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Memory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Cellular Senescence
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes
Drugs
Diseases			Hairy-cell leukemia
GWAS		Asthma ( 27611488) Chronotype ( 30696823) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Macular thickness ( 30535121) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 23894747)	Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Asthma ( 31959851) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438)
Interacting Genes		5 interacting genes: BCL6 HDAC6 SKP1 TP53 USP16	89 interacting genes: ANKRD53 ARHGEF9 ARRDC3 ATP23 BCL11A BCL6B BCOR BLZF1 C4orf45 C7orf31 C9orf24 CABP4 CDK19 CDK8 CFAP161 CFAP97D1 CHD3 CNOT2 CRBN CREBBP CTNNB1 CUTC DVL2 ENO1 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 KLHL12 KLHL20 KRTAP13-1 KRTAP13-2 KRTAP19-1 LIMS3 LIMS4 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PBX4 PELI1 PFDN5 PIN1 PML POF1B PPARD PPTC7 PRKD3 PSMB4 RAF1 REL RUNX1T1 SIAH1 SIN3A SP1 SPI1 SSX2IP TEKT4 TFIP11 TLE5 TP53 TP53BP1 TRAF1 TRAF2 TRIB3 TWIST1 WDR83 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B ZNHIT1
Entrez ID		80204	604
HPRD ID		06985	00180
Ensembl ID		ENSG00000138081	ENSG00000113916
Uniprot IDs		Q86XK2	B5B0A5 P41182
PDB IDs		5VMD	1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8 6TOF 6TOG 6TOH 6TOI 6TOJ 6TOK 6TOL 6TOM 6TON 6TOO
Enriched GO Terms of Interacting Partners?
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