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CALM1 and REL
Data Source:
HPRD
(in vitro)
CALM1
REL
Description
calmodulin 1
REL proto-oncogene, NF-kB subunit
Image
No pdb structure
GO Annotations
Cellular Component
Spindle Pole
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Spindle Microtubule
Plasma Membrane
Voltage-gated Potassium Channel Complex
Sarcomere
Growth Cone
Synaptic Vesicle Membrane
Mitochondrial Membrane
Vesicle
Protein-containing Complex
Calcium Channel Complex
Myelin Sheath
Catalytic Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Molecular Function
Calcium Ion Binding
Protein Binding
Adenylate Cyclase Binding
Adenylate Cyclase Activator Activity
Calcium Channel Inhibitor Activity
Protein Kinase Binding
Protein Domain Specific Binding
Enzyme Regulator Activity
Nitric-oxide Synthase Regulator Activity
Titin Binding
Type 3 Metabotropic Glutamate Receptor Binding
N-terminal Myristoylation Domain Binding
Protein Serine/threonine Kinase Activator Activity
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Calcium-dependent Protein Binding
Nitric-oxide Synthase Binding
Protein Phosphatase Activator Activity
Disordered Domain Specific Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
MAPK Cascade
Response To Amphetamine
Regulation Of Heart Rate
Platelet Degranulation
Detection Of Calcium Ion
Glycogen Catabolic Process
Muscle Contraction
G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Wnt Signaling Pathway, Calcium Modulating Pathway
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Viral Process
Substantia Nigra Development
Regulation Of Rhodopsin Mediated Signaling Pathway
Positive Regulation Of Protein Autophosphorylation
Regulation Of Cytokinesis
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Protein Dephosphorylation
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of DNA Binding
Inositol Phosphate Metabolic Process
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Response To Corticosterone
Response To Calcium Ion
Regulation Of Cardiac Muscle Contraction
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Establishment Of Protein Localization To Mitochondrial Membrane
Regulation Of Cardiac Muscle Cell Action Potential
Regulation Of Synaptic Vesicle Endocytosis
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Negative Regulation Of Interferon-beta Production
Cellular Response To Stress
Response To Cytokine
NIK/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Neuron Death
Pathways
CaMK IV-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
Calmodulin induced events
Cam-PDE 1 activation
CaM pathway
Platelet degranulation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
PKA activation
DARPP-32 events
Synthesis of IP3 and IP4 in the cytosol
Calcineurin activates NFAT
Calcineurin activates NFAT
eNOS activation
Transcriptional activation of mitochondrial biogenesis
Inactivation, recovery and regulation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Stimuli-sensing channels
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ras activation upon Ca2+ influx through NMDA receptor
Smooth Muscle Contraction
Smooth Muscle Contraction
Activation of Ca-permeable Kainate Receptor
Uptake and function of anthrax toxins
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
Phase 0 - rapid depolarisation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
CLEC7A (Dectin-1) induces NFAT activation
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Glycogen breakdown (glycogenolysis)
Glycogen breakdown (glycogenolysis)
Protein methylation
Extra-nuclear estrogen signaling
Loss of phosphorylation of MECP2 at T308
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Negative regulation of NMDA receptor-mediated neuronal transmission
Activation of RAC1 downstream of NMDARs
Activation of RAC1 downstream of NMDARs
Activation of AMPK downstream of NMDARs
Long-term potentiation
Long-term potentiation
RAS processing
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Activation of NF-kappaB in B cells
Drugs
Chlorpromazine
Cinchocaine
Nicardipine
Fluphenazine
Isoflurane
Trifluoperazine
Loperamide
Perphenazine
Phenoxybenzamine
Felodipine
Melatonin
Promethazine
Pimozide
Nifedipine
Bepridil
Calcium
Aprindine
Deacetoxyvinzolidine
tert-butanol
Trimethyllysine
N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Prenylamine
Flunarizine
(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE
Myristic acid
Calcium citrate
Calcium citrate
Calcium citrate
Calcium Phosphate
Calcium Phosphate
Calcium Phosphate
Calcium levulinate
Calcium phosphate dihydrate
Calcium phosphate dihydrate
Calcium phosphate dihydrate
Diseases
Hodgkin lymphoma
GWAS
Leukocyte telomere length (
32109421
)
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
22412388
21102463
)
Erectile dysfunction (
30583798
)
Hodgkin's lymphoma (
21037568
24920014
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
25903422
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
26626624
22170493
)
Rheumatoid arthritis (
30423114
23143596
24390342
20453842
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Ulcerative colitis (
20228799
)
Interacting Genes
261 interacting genes:
ACADM
ACE2
ADCY8
ADCYAP1R1
ADD1
ADD2
AKAP5
AKAP6
AKAP9
AR
ARHGEF7
ARMC1
ASCL2
ATP2B1
ATRX
BRWD1
C11orf65
C4orf3
CABIN1
CALCR
CALD1
CAMK1
CAMK2G
CAMKK1
CAMKK2
CAMTA2
CASP8AP2
CCDC14
CCNA2
CCND1
CCND2
CCNE1
CCP110
CDC37L1
CDC5L
CKMT1B
CLINT1
CLIP1
CLTB
CNGA2
CNN1
CRHR1
CSNK2A1
CSNK2A2
CSNK2B
DAPK1
DCTN2
DCUN1D1
DDAH1
DDIT4L
DDX21
DDX5
DLG3
DMXL1
DNAJC13
DOCK11
DOCK3
DRD2
DST
EDF1
EGFR
EIF3C
ERBB2
ERBB3
ESR1
ESR2
ESRRG
EWSR1
FAS
FBXO9
FER
FKBP3
FKBP4
GAP43
GCLM
GEM
GJB1
GLP1R
GLP2R
GNAS
GRB7
GRIN1
GRK1
GRK4
GRK5
GRM3
GRM4
GRM5
GRM7
GSC2
GTF2I
H2AX
HERC2
HMMR
HSP90AA1
HSPA4
HTR2C
HUWE1
IDH1
IMMT
INSR
IQCE
IQCG
IQCN
IQGAP1
IQGAP2
ITGA6
ITPKA
ITPKB
KCNB1
KCNH1
KCNN1
KCNN2
KCNN3
KCNN4
KCNQ2
KCNQ3
KCNQ5
KDM5C
KIF1B
KRAS
LACTB
LINC00839
LMO7
LTF
LUC7L
LY96
LYST
MAPT
MATR3
MBIP
METAP2
MFHAS1
MIP
MORF4L1
MYBPC1
MYC
MYCBP2
MYF5
MYF6
MYLK
MYO10
MYO5A
MYO7A
MYO9B
MYOD1
MYOG
NBR1
NEB
NEUROD1
NEXN
NOL7
NOS3
NR3C1
NRGN
NSMF
NT5C2
OBSCN
OPALIN
OPRM1
OPTN
PAM
PCNT
PCP4
PDCD7
PDE1A
PHACTR4
PHKB
PHKG1
PIK3C3
PLA2G6
PLCD1
POC5
POLR2B
PPEF1
PPEF2
PPIL2
PRDX1
PSMD12
PSMD2
PTAFR
PTEN
PTH2R
PTPRA
PUM3
RAB3B
RAD23B
RALA
RALB
RANBP2
RDX
REL
RELA
RGS10
RGS2
RGS4
RIT2
RPL13A
RPL22
RPS14
RPS15A
RPS4Y1
RPS8
RRAD
RS1
RYR1
S100B
SCAPER
SCLT1
SCN4A
SCN5A
SCTR
SDCBP
SEC61A1
SET
SF3B1
SLF2
SLTM
SNCA
SNRPB2
SNTA1
SNX6
SPATA17
SPP1
SQSTM1
SRP14
SRSF5
STAG1
STIM2
STK38
STRN
STRN3
STRN4
STX8
SUMO2
SYK
SYNE2
SYT1
TBC1D1
TCF3
TCF4
THOP1
TNNI2
TPT1
TRDN
TRPC3
TRPV1
TRPV4
TRPV6
TSC2
TTN
UBR4
UCHL5
USP16
UTRN
VIPR1
XRCC4
YBX1
YWHAE
ZBTB24
ZNF280A
319 interacting genes:
A1CF
AAAS
ACBD4
ACOT12
ACOT8
ACTN3
ADRB2
ADSL
AGPAT4
AKT2
ALOX5
AQP1
AR
ARFIP2
ARIH2
ARL16
ARMC7
ARNT2
ASAP3
ASMTL
ATG9A
ATP6V0D2
ATP6V1C2
ATPAF2
ATXN1
BANP
BARHL2
BBS4
BCL2L15
BCL6
BID
BMF
C11orf68
C12orf75
C14orf119
C1orf109
C1orf50
C1orf56
C1orf74
C9orf72
CABP5
CACNA1S
CALM1
CCNC
CCNE1
CCNJL
CDK18
CDKN1A
CDKN2C
CDKN2D
CDR2L
CENPX
CEP19
CFAP206
CGGBP1
CHAF1A
CHCHD2
CHIC2
CIB3
CINP
CKS1B
CLIC4
CLIP1
COL20A1
COL8A1
CPNE2
CPNE7
CPSF1
CSNK2A1
CTNNA3
CTNNBIP1
CXCL14
CYB5R2
DAAM2
DDX6
DEF6
DGCR6
DHPS
DMRT3
DNTT
DPF2
DYNC1LI1
EFHC1
EHHADH
EIF3A
EIF3D
EIF4A3
EIF4E2
EIF4EBP1
EIF5A
EIF5A2
ELF1
EMD
EML2
EP300
EPHB6
EPM2AIP1
ESRRA
ESRRG
EXOSC1
EXOSC5
EXOSC8
FAAP20
FAM90A1
FHIT
FHL2
FKBP1B
FLAD1
FLNA
FNDC11
FNDC3B
FOXO4
FUT11
GADD45G
GLYCTK
GPKOW
GRAP
GRB2
GTF2B
HAT1
HDAC7
HIP1
HLA-DOA
HNRNPF
HNRNPLL
HSD17B14
HSPA4
HSPA8
HSPB7
IL36RN
KCTD6
KCTD7
KIAA0100
KLHL32
KLHL40
KLHL42
KRTAP9-4
L3MBTL2
LASP1
LENG1
LGALS14
LMO1
LMO2
LNPEP
LSM2
MAD2L2
MAGOHB
MAP3K7CL
MAP3K8
MAPK8
MAPRE3
MB21D2
MBD3
MEMO1
MID2
MIEN1
MIPOL1
MLIP
MMP2
MORF4L1
MORF4L2
MRPL10
MSRB3
MTPN
MTURN
MVP
MYO15B
NABP1
NAGK
NCK2
NDE1
NDUFAF3
NECAP1
NEDD9
NEIL2
NEUROG3
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NGB
NKRF
NME7
NMRK1
NOL9
NOTCH1
NOXA1
NR2C2AP
NUCB1
NUDT10
NUDT14
NXT2
OAZ3
OSGIN1
OSTF1
OTUB2
OTUD4
PADI3
PAK1IP1
PARVG
PATE1
PCYT2
PELI2
PGAP6
PICK1
PIH1D2
PLCB4
PLEKHN1
PM20D2
POLE2
POLR1A
POLR2L
POP5
PPP4C
PRDM10
PRKAA2
PRKAB2
PRKN
PRPF31
PSMA1
PSMA4
PSMB8
PSORS1C2
PTGER3
PTK6
QARS1
R3HDM2
RAB29
RAB41
RABIF
RAD23A
RAD51D
RASSF5
RBM39
RECK
RELA
REXO1L6P
RIPPLY1
RNF213
RNF6
RSPH14
RTL8C
RUNX1T1
S100A1
SAMD11
SAT1
SCNM1
SDCBP
SEC14L4
SEC31A
SEPTIN7
SHC3
SIN3A
SIX1
SLC39A13
SLC41A3
SLC6A12
SMG9
SNRNP25
SP1
SPATC1L
SPG21
SPRY1
SRF
STAMBPL1
STK16
SULT2B1
SUOX
SZT2
TBC1D21
TBC1D22B
TBP
TCL1A
TCP11L1
TDO2
THOC1
TLE5
TLX3
TMEM165
TMEM268
TNIP2
TNS2
TRAPPC2L
TRAPPC6A
TRIM27
TRIM68
TRIM74
TSC22D3
TSEN15
TSPOAP1
TSSC4
TSSK3
TSTD2
TTC19
TTC21A
TXNL4B
UBASH3A
UBASH3B
UBE2D4
UBE2K
UBE2Z
UBXN7
VPS25
WNK3
YARS1
YJU2
ZBED8
ZBTB16
ZDHHC24
ZIC1
ZNF417
ZNF446
ZNF550
ZNF564
ZNF572
ZNF688
ZNF76
ZNF765
Entrez ID
801
5966
HPRD ID
00241
01286
Ensembl ID
ENSG00000198668
ENSG00000162924
Uniprot IDs
B4DJ51
P0DP23
P0DP24
P0DP25
Q04864
PDB IDs
1AJI
1CDL
1CLL
1CTR
1IWQ
1J7O
1J7P
1K90
1K93
1L7Z
1LVC
1NKF
1PK0
1S26
1SK6
1SW8
1UP5
1WRZ
1XFU
1XFV
1XFW
1XFX
1XFY
1XFZ
1Y6W
1YR5
1YRT
1YRU
1ZOT
1ZUZ
2BE6
2F3Y
2F3Z
2HF5
2I08
2JZI
2K0E
2K0F
2K0J
2K61
2KNE
2KUG
2KUH
2L53
2L7L
2LGF
2LL6
2LL7
2LQC
2LQP
2LV6
2M0J
2M0K
2M55
2MG5
2N27
2N6A
2N77
2N8J
2R28
2V01
2V02
2VAY
2W73
2WEL
2X0G
2Y4V
3BYA
3DVE
3DVJ
3DVK
3DVM
3EWT
3EWV
3G43
3HR4
3J41
3O77
3O78
3OXQ
3SUI
3UCT
3UCW
3UCY
4BW7
4BW8
4BYF
4DCK
4DJC
4GOW
4JPZ
4JQ0
4L79
4LZX
4M1L
4OVN
4Q57
4Q5U
4UMO
4UPU
4V0C
5COC
5DBR
5DOW
5DSU
5GGM
5I0I
5J03
5J8H
5JQA
5JTH
5K7L
5K8Q
5NIN
5OEO
5TP5
5TP6
5V02
5V03
5V7X
5VMS
5WBX
5WC5
5WSU
5WSV
6B8L
6B8M
6B8N
6B8P
6B8Q
6BUT
6C1D
6C1G
6C1H
6CNM
6CNN
6CNO
6DAD
6DAE
6DAF
6DAH
6E2F
6E2G
6EEB
6FEG
6FEH
6GDK
6GDL
6HCS
6HR1
6JI8
6JII
6JIU
6JIY
6JRS
6JV2
6K4K
6K4L
6K4R
6K67
6M2W
6M7H
6MUD
6MUE
6N5W
6O5G
6OS4
6PAW
6PBX
6PBY
6PLM
6S5T
6SZ5
6U39
6U3A
6U3B
6U3D
6UZZ
6V00
6V01
6Y4O
6Y4P
6Y94
6Y95
7CR3
7CR4
7CR7
Enriched GO Terms of Interacting Partners
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