MCMBP and MCM5

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MCMBP	MCM5
Description		minichromosome maintenance complex binding protein	minichromosome maintenance complex component 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cell Junction MCM Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane MCM Complex CMG Complex
	Molecular Function	Chromatin Binding Protein Binding	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	DNA-dependent DNA Replication Sister Chromatid Cohesion Cell Division	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Duplex Unwinding
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Height ( 28552196)	Chronotype ( 30696823) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: ASL DBF4 DDIT3 FKBP5 KEAP1 MCM3 MCM4 MCM5 MCM6 MCM7 PRTFDC1 RWDD2A SNW1 USP7 ZNF474	28 interacting genes: APP CDC5L CDC7 CDKN2A EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG
Entrez ID		79892	4174
HPRD ID		07624	04075
Ensembl ID		ENSG00000197771	ENSG00000100297
Uniprot IDs		A0A0S2Z5P5 Q9BTE3	B1AHB0 P33992
PDB IDs		4KG9	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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