RPAP2 and PIH1D1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		RPAP2	PIH1D1
Description		RNA polymerase II associated protein 2	PIH1 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol RNA Polymerase II, Holoenzyme	Nucleus Nucleolus Cytoplasm Pre-snoRNP Complex R2TP Complex Ribonucleoprotein Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity RNA Polymerase Core Enzyme Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Protein Kinase Binding Histone Binding ATPase Binding Phosphoprotein Binding
	Biological Process	SnRNA Transcription SnRNA Transcription By RNA Polymerase II Dephosphorylation Of RNA Polymerase II C-terminal Domain	Box C/D SnoRNP Assembly RNA Polymerase I Preinitiation Complex Assembly Chromatin Remodeling RRNA Processing Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly SnoRNA Localization Regulation Of Histone H3-K4 Methylation Establishment Of Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of TORC2 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494 27863252)
Interacting Genes		5 interacting genes: GPN1 ITCH NEDD4 PIH1D1 PLEKHF2	20 interacting genes: BYSL CA4 CDCA7L EAF1 FAM90A1 FARP1 GEM LRCH3 MAPK6 MFAP1 MISP PLEKHN1 RBPMS RCOR3 RPAP2 SCNM1 SEPTIN1 SMARCD1 TNS4 TSC22D4
Entrez ID		79871	55011
HPRD ID		07814	07938
Ensembl ID		ENSG00000122484	ENSG00000104872
Uniprot IDs		Q8IXW5	Q9NWS0
PDB IDs			4PSF 4PSI 6GXZ
Enriched GO Terms of Interacting Partners?
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