TMC5 and NUMBL

Data Source:
BioGRID (two hybrid)

		TMC5	NUMBL
Description		transmembrane channel like 5	NUMB like endocytic adaptor protein
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Mechanosensitive Ion Channel Activity	Protein Binding
	Biological Process	Ion Transmembrane Transport	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis
Pathways
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 31170924) Nicotine dependence symptom count ( 25555482) Sleep duration ( 23728906)	Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22446962) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730)
Interacting Genes		1 interacting genes: NUMBL	23 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG
Entrez ID		79838	9253
HPRD ID		15516	04931
Ensembl ID		ENSG00000103534	ENSG00000105245
Uniprot IDs		B7Z5K3 B7Z946 F5GYU8 Q6UXY8	A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0
PDB IDs			3F0W
Enriched GO Terms of Interacting Partners?
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