TLE6 and FOXG1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TLE6	FOXG1
Description		TLE family member 6, subcortical maternal complex member	forkhead box G1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cell Cortex Protein-containing Complex Subcortical Maternal Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Actin Filament Organization Positive Regulation Of Embryonic Development Establishment Of Spindle Localization Regulation Of Cell Division Endoplasmic Reticulum Localization Mitochondrion Localization Embryonic Process Involved In Female Pregnancy Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Brain Development Aging Dorsal/ventral Pattern Formation Axon Midline Choice Point Recognition Pyramidal Neuron Migration Inner Ear Morphogenesis Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Neuron Fate Determination
Pathways			Regulation of MECP2 expression and activity FOXO-mediated transcription of cell cycle genes
Drugs
Diseases			Rett syndrome
GWAS			Longevity ( 20834067) Manganese levels ( 26025379) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry) ( 24825563) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)
Interacting Genes		4 interacting genes: FOXG1 RIPK3 RPL14 TRIM54	19 interacting genes: APOE AR EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 SRF TLE1 TLE3 TLE6
Entrez ID		79816	2290
HPRD ID		18195	01283
Ensembl ID		ENSG00000104953	ENSG00000176165
Uniprot IDs		Q6PJM9 Q9H808	P55316
PDB IDs			7CBY
Enriched GO Terms of Interacting Partners?
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