ALG9 and BHMT

Data Source:
BioGRID (two hybrid)

		ALG9	BHMT
Description		ALG9 alpha-1,2-mannosyltransferase	betaine--homocysteine S-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Cytosol Extracellular Exosome
	Molecular Function	Alpha-1,2-mannosyltransferase Activity Mannosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l)	Sulfur amino acid metabolism Choline catabolism
Drugs			Methionine S-(D-Carboxybutyl)-L-Homocysteine
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)
Interacting Genes		2 interacting genes: BHMT H2AX	6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		79796	635
HPRD ID		09504	04200
Ensembl ID		ENSG00000086848	ENSG00000145692
Uniprot IDs		Q9H6U8	Q93088 V9HWA4
PDB IDs			1LT7 1LT8 4M3P
Enriched GO Terms of Interacting Partners?
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