FBXO31 and CDT1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		FBXO31	CDT1
Description		F-box protein 31	chromatin licensing and DNA replication factor 1
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GO Annotations	Cellular Component	Centrosome Cytosol SCF Ubiquitin Ligase Complex Neuronal Cell Body	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Protein Binding Cyclin Binding	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding
	Biological Process	Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Neuron Migration	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromosome Segregation Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization DNA Replication Preinitiation Complex Assembly Response To Sorbitol Deactivation Of Mitotic Spindle Assembly Checkpoint Regulation Of DNA Replication Origin Binding Negative Regulation Of Protein Localization To Kinetochore Positive Regulation Of Protein Localization To Kinetochore Positive Regulation Of DNA-dependent DNA Replication
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 22472876) Neurociticism ( 29500382) Neuroticism ( 29255261)	Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978 28017375) Mean corpuscular volume ( 29403010)
Interacting Genes		5 interacting genes: AKT1 CCND1 CDT1 GHR MDM2	28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM2 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		79791	81620
HPRD ID		10954	06900
Ensembl ID		ENSG00000103264	ENSG00000167513
Uniprot IDs		A0A0C4DGU8 Q5XUX0	Q9H211
PDB IDs		5VZT 5VZU	2LE8 2WVR 6QCG
Enriched GO Terms of Interacting Partners?
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