TBL1XR1 and ARL2

Data Source:
BioGRID (two hybrid)

		TBL1XR1	ARL2
Description		TBL1X receptor 1	ADP ribosylation factor like GTPase 2
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Intermembrane Space Mitochondrial Matrix Golgi Apparatus Centrosome Cytosol Focal Adhesion Cilium Microtubule Cytoskeleton Lateral Plasma Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding Protein N-terminus Binding	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Regulation Of Lipid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Canonical Wnt Signaling Pathway	Tubulin Complex Assembly Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Regulation Of Insulin Secretion Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events	Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing
Drugs			Tagraxofusp
Diseases
GWAS		Asthma ( 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Central corneal thickness ( 32528159 31798171 29760442) Chin dimples ( 27182965) Chronotype ( 30696823) Corneal structure ( 23291589) Esophageal cancer ( 21642993) Inflammatory skin disease ( 25574825) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)
Interacting Genes		12 interacting genes: ARL2 CORO2A FOXK2 GPS2 H2BC21 H4C14 H4C6 HDAC3 MECP2 NCOR1 TBL1X UBE2I	6 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1XR1 UNC119
Entrez ID		79718	402
HPRD ID		15476	11869
Ensembl ID		ENSG00000177565	ENSG00000213465
Uniprot IDs		Q9BZK7	P36404 Q53YD8
PDB IDs		4LG9	3DOE 3DOF
Enriched GO Terms of Interacting Partners?
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