PPP1R3B and IFNAR2

Data Source:
BioGRID (two hybrid)

		PPP1R3B	IFNAR2
Description		protein phosphatase 1 regulatory subunit 3B	interferon alpha and beta receptor subunit 2
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Glycogen Granule Intracellular Membrane-bounded Organelle	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity [phosphorylase] Phosphatase Activity Glycogen Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity	Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin
Diseases
GWAS		Acne (severe) ( 24927181) Alcohol use disorder (consumption score) ( 30940813) Aluminium levels ( 26025379) Alzheimer's disease ( 22832961) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Fibrinogen levels ( 28107422) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pregnancy) ( 23903356) Glycine levels ( 31070104) HDL cholesterol ( 23726366 24097068 23505323 21347282 25961943 20686565) HDL cholesterol levels ( 28334899) Iron status biomarkers (total iron binding capacity) ( 28334935) Joint mobility (Beighton score) ( 27182965) LDL cholesterol ( 24097068 20864672 25961943 20686565) LDL cholesterol levels ( 28334899) Liver enzyme levels (alkaline phosphatase) ( 22001757) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Myopia (pathological) ( 23049088) Neuroticism ( 29255261) Nose size ( 27182965) Number of sexual partners ( 30643258) Peak expiratory flow ( 30804560) Plasma lactate levels ( 26433129) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total cholesterol levels ( 28334899)	Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)
Interacting Genes		7 interacting genes: IFNAR2 PLCE1 PPP1CA PPP1CB PPP1CC PYGB PYGM	14 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		79660	3455
HPRD ID		17894	03850
Ensembl ID		ENSG00000173281	ENSG00000159110
Uniprot IDs		Q86XI6	P48551 Q9BUA0
PDB IDs		2EEF 5ZT0	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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