THTPA and PDE6B

Data Source:
BioGRID (biochemical)

		THTPA	PDE6B
Description		thiamine triphosphatase	phosphodiesterase 6B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Magnesium Ion Binding Protein Binding Hydrolase Activity Thiamin-triphosphatase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Thiamine Metabolic Process Dephosphorylation Thiamine Diphosphate Metabolic Process Thiamine-containing Compound Metabolic Process	Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Retina Development In Camera-type Eye
Pathways		Vitamin B1 (thiamin) metabolism	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs			Caffeine Trapidil
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS
Interacting Genes		1 interacting genes: TLX3
Entrez ID		79178	5158
HPRD ID		15505	01571
Ensembl ID		ENSG00000259431	ENSG00000133256
Uniprot IDs		G3V5Q5 Q9BU02	B4DHV7 P35913
PDB IDs		3BHD 3TVL
Enriched GO Terms of Interacting Partners?
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