ALDH5A1 and ABAT

Data Source:
HPRD (in vitro)

		ALDH5A1	ABAT
Description		aldehyde dehydrogenase 5 family member A1	4-aminobutyrate aminotransferase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix 4-aminobutyrate Transaminase Complex
	Molecular Function	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Identical Protein Binding	4-aminobutyrate Transaminase Activity Pyridoxal Phosphate Binding Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate:2-oxoglutarate Transaminase Activity Identical Protein Binding Metal Ion Binding (S)-3-amino-2-methylpropionate Transaminase Activity Iron-sulfur Cluster Binding
	Biological Process	Succinate Metabolic Process Glutamate Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Neurotransmitter Catabolic Process	Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Catabolic Process Neurotransmitter Catabolic Process Behavioral Response To Cocaine
Pathways		Degradation of GABA	Degradation of GABA
Drugs		Succinic acid NADH Valproic acid Chlormerodrin	Pyridoxal phosphate Pyruvic acid Glutamic acid Alanine Phenelzine Vigabatrin (4e)-4-Aminohex-4-Enoic Acid 4-Amino Hexanoic Acid
Diseases		Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)	Anger ( 24489884) Bronchopulmonary dysplasia in preterm infants ( 30113228) Menopause (age at onset) ( 26414677) Response to opioid analgesics in cancer (pain decrease) ( 30277654)
Interacting Genes		2 interacting genes: ABAT MAGEA11	1 interacting genes: ALDH5A1
Entrez ID		7915	18
HPRD ID		08361	00661
Ensembl ID		ENSG00000112294	ENSG00000183044
Uniprot IDs		P51649 X5D299 X5DQN2	P80404 X5D8S1
PDB IDs		2W8N 2W8O 2W8P 2W8Q 2W8R
Enriched GO Terms of Interacting Partners?
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