ALG8 and RSF1

Data Source:
HPRD (in vitro)

		ALG8	RSF1
Description		ALG8 alpha-1,3-glucosyltransferase	remodeling and spacing factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Nucleoplasm RSF Complex
	Molecular Function	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Transcription Coregulator Activity Protein Binding ATPase Activity Histone Binding Metal Ion Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation	Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription, Initiation Nucleosome Positioning CENP-A Containing Nucleosome Assembly Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Depression in smokers ( 30219690) Tourette syndrome ( 30818990)	Left-handedness ( 32989287) Tourette syndrome ( 30818990)
Interacting Genes		12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A	3 interacting genes: CSNK2A1 NFKB1 SMARCA5
Entrez ID		79053	51773
HPRD ID		10480	10537
Ensembl ID		ENSG00000159063	ENSG00000048649
Uniprot IDs		A0A024R5K5 Q9BVK2	Q05DG0 Q96T23
PDB IDs
Enriched GO Terms of Interacting Partners?
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