GGCT and DNAH11

Data Source:
BioGRID (affinity chromatography technology)

		GGCT	DNAH11
Description		gamma-glutamylcyclotransferase	dynein axonemal heavy chain 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Microtubule Axoneme Dynein Complex Motile Cilium 9+2 Motile Cilium Proximal Portion Of Axoneme
	Molecular Function	Gamma-glutamylcyclotransferase Activity Protein Homodimerization Activity	ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Glutathione Biosynthetic Process	Cilium Movement Regulation Of Cilium Beat Frequency Microtubule-based Movement Determination Of Left/right Symmetry Flagellated Sperm Motility
Pathways		Glutathione synthesis and recycling
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS			Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bone mineral density (hip) ( 30172743) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cholesterol, total ( 24097068 19060911 25961943 20686565) Cognitive decline (age-related) ( 24468470) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) LDL cholesterol ( 24097068 19060911 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multiple myeloma ( 22120009 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) PR interval ( 32439900) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels ( 28334899 30275531) Total ventricular volume ( 21116278) Whole-brain volume ( 21116278)
Interacting Genes		1 interacting genes: APP
Entrez ID		79017	8701
HPRD ID		12912	09134
Ensembl ID		ENSG00000006625	ENSG00000105877
Uniprot IDs		A0A090N7V5 O75223	H9NAJ7 H9NAJ8 Q96DT5 Q96NT7
PDB IDs		2I5T 2PN7 2Q53 2RBH 3CRY
Enriched GO Terms of Interacting Partners?
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