SCG2 and TUBB4B

Data Source:
BioGRID (two hybrid)

		SCG2	TUBB4B
Description		secretogranin II	tubulin beta 4B class IVb
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Neuronal Dense Core Vesicle	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	Cytokine Activity Protein Binding Chemoattractant Activity	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Unfolded Protein Binding
	Biological Process	MAPK Cascade Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response Protein Secretion Intracellular Signal Transduction Endothelial Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Eosinophil Chemotaxis Positive Chemotaxis Induction Of Positive Chemotaxis Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Ciliary Basal Body-plasma Membrane Docking
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate
Diseases
GWAS		Airway wall thickness ( 25517131) Depression in smokers ( 30219690) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Night sleep phenotypes ( 27126917) Osteoporosis-related phenotypes ( 20200953) Response to hepatitis C treatment ( 22095909) Sodium levels ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		4 interacting genes: ATRIP TUBB4B UBQLN1 UBQLN4	19 interacting genes: ACD CDKN2A DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 POT1 PSME1 PTEN PTPRF SCG2 SOCS6 SOCS7 SUMO2 TERF1 TINF2 TUBG1
Entrez ID		7857	10383
HPRD ID		06762	04043
Ensembl ID		ENSG00000171951	ENSG00000188229
Uniprot IDs		P13521	P68371
PDB IDs
Enriched GO Terms of Interacting Partners?
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