FZD5 and LZTFL1

Data Source:
BioGRID (two hybrid)

		FZD5	LZTFL1
Description		frizzled class receptor 5	leucine zipper transcription factor like 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Cell Surface Integral Component Of Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perikaryon Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity Protein-containing Complex Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Embryonic Axis Specification Angiogenesis Positive Regulation Of T Cell Cytokine Production G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Camera-type Eye Morphogenesis Spemann Organizer Formation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Disassembly Regulation Of Bicellular Tight Junction Assembly	Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization To Ciliary Membrane
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494)	Acne (severe) ( 24927181) COVID-19 (critical illness vs population) ( 33307546) Eosinophil percentage of white cells ( 32888494) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 31604244) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		13 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A	10 interacting genes: EHHADH FZD5 MOB1A NTAQ1 PELI2 PICK1 PSMA1 PSMB1 SDCBP TRIM68
Entrez ID		7855	54585
HPRD ID		03427	07586
Ensembl ID		ENSG00000163251	ENSG00000163818
Uniprot IDs		Q13467	Q9NQ48
PDB IDs		5URY 5URZ 6O39 6WW2
Enriched GO Terms of Interacting Partners?
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