CSDE1 and WFS1

Data Source:
BioGRID (two hybrid)

		CSDE1	WFS1
Description		cold shock domain containing E1	wolframin ER transmembrane glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	P-body Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite
	Molecular Function	RNA Binding Protein Binding RNA Stem-loop Binding	Protein Binding Ubiquitin Protein Ligase Binding ATPase Binding
	Biological Process	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Type II diabetes mellitus Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Autism ( 24189344)	Cisplatin-induced ototoxicity ( 28039263) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 19734900 29632382 31118516 32499647 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		10 interacting genes: C11orf68 ERBB2 FAM9B HID1 HNRNPD PABPC1 PCSK7 STT3A SYNCRIP WNK1	11 interacting genes: AQP6 CD79A DRD2 EIF6 F2RL1 FAM209A LTB4R2 MAPK6 SMURF1 TERF1 TRARG1
Entrez ID		7812	7466
HPRD ID		15949	05864
Ensembl ID		ENSG00000009307	ENSG00000109501
Uniprot IDs		A0A024R0E2 A0A024R0K2 O75534	A0A0S2Z4V6 O76024
PDB IDs		1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?
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