PRDM2 and BBS5

Data Source:
BioGRID (affinity chromatography technology)

		PRDM2	BBS5
Description		PR/SET domain 2	Bardet-Biedl syndrome 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Methyltransferase Activity Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Determination Of Adult Lifespan Regulation Of Gene Expression Methylation Positive Regulation Of Transcription By RNA Polymerase II	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronotype ( 30696823) Copper levels ( 26025379) Intracranial aneurysm ( 30823506) Left ventricular function change in anthracycline treatment ( 28542097) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Parkinson's disease ( 26227905) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Refractive error ( 32231278)	Iris heterochromicity ( 30895295)
Interacting Genes		6 interacting genes: E2F1 ESR1 H3-4 H3C1 MDM2 RB1	2 interacting genes: CRADD KLC3
Entrez ID		7799	129880
HPRD ID		03120	10353
Ensembl ID		ENSG00000116731	ENSG00000163093
Uniprot IDs		Q13029	A0A0S2Z626 Q8N3I7
PDB IDs		2JV0 2QPW	6XTB
Enriched GO Terms of Interacting Partners?
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