ZNF184 and SOX6

Data Source:
BioGRID (two hybrid)

		ZNF184	SOX6
Description		zinc finger protein 184	SRY-box transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Muscle Organ Development Spinal Cord Oligodendrocyte Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Astrocyte Differentiation Cartilage Development Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Generic Transcription Pathway	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Fish- and plant-related diet ( 32066663) Hemoglobin levels ( 32327693) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Modic changes ( 30808802) Parkinson's disease ( 27182965 28892059) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 19571809) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 24871463) Triglyceride levels ( 32203549)	Adolescent idiopathic scoliosis ( 30395268) Anti-saccade response ( 25387707) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 23972371) Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (wrist) ( 21104366) Capecitabine sensitivity ( 22864933) Chronotype ( 30696823) Coronary artery disease ( 29212778 33020668) Cotinine glucuronidation ( 25293881) Diastolic blood pressure ( 27841878 25249183 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Experiencing mood swings ( 29500382) Femoral neck bone mineral density ( 29499414 32239398 26367794 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) General factor of neuroticism ( 30867560) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 25249183) Left-handedness ( 32989287) Longevity (90 years and older) ( 25199915) Lumbar spine bone mineral density ( 26367794) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity and osteoporosis ( 19714249) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systolic blood pressure ( 27841878 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 31046077)
Interacting Genes		4 interacting genes: CLIC1 EWSR1 SOX6 UBP1	12 interacting genes: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2I ZNF184
Entrez ID		7738	55553
HPRD ID		03785	06267
Ensembl ID		ENSG00000096654	ENSG00000110693
Uniprot IDs		A0A024RCM2 Q99676	P35712
PDB IDs
Enriched GO Terms of Interacting Partners?
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